Assistant Professor

Ph:
Off: +91-80-2293 2914
E-mail: subinoy@iisc.ac.in

Brief Biodata:

Subinoy Rana obtained his B.Sc. in Chemistry from Ramakrishna Mission Residential College Narendrapur (University of Calcutta, 2005), followed by M.Sc. in Chemistry from Indian Institute of Technology Madras (2007) and Ph.D. from the University of Massachusetts Amherst, USA (2012). He was a postdoctoral research associate at Imperial College London, UK (2013-2017) with the Marie Curie Fellowship. After a brief stint as Assistant Professor at Newcastle University, UK (2017-2018), Subinoy has joined Indian Institute of Science Bangalore as an Assistant Professor in Bionanochemistry. His laboratory aims to develop functional materials for interfacing with biology, focusing on diagnostics and precision medicine. 

Research:
The central theme of our interdisciplinary research is an emerging area of nanobiotechnology: the role of biomaterials surface chemistry in modulating the materials-biology interface. This work is particularly crucial for biological applications of materials given the central role of surface chemistry in constructing biomaterials with appropriate functionalities and biocompatibility. Our research has demonstrated the utility of these novel materials in different bio-applications including diagnostics, drug discovery and therapeutic delivery. Long-term, we aim to innovate effective point-of-care diagnostics for different diseases with personalized screening abilities, novel platforms for precision medicine, and tissue engineering incorporating the desired materials properties.

Current research topics are:
Ultrasensitive biosensing strategies
Tailorable soft materials
Nano-emulsions and vesicles
Metal nanoclusters
Self-assembly of nanomaterials

Selected Publications:

  • Holme, M.N.;# Rana, S.;# Barriga, H.M.G.; Kauscher, U.; Brooks, N.J.; Stevens, M.M. A robust liposomal platform for direct colorimetric detection of sphingomyelinase enzyme and inhibitors. ACS Nano 12, 8197-8207 (2018). | #Equal contribution

  • Rana, S.;* Elci, S.G.; Mout, R.; Singla, A.K.; Yazdani, M.; Bendur, M.; Bajaj, A.; Saha, K.; Bunz, U.H.F.; Jirik, F.R.; Rotello, V.M.* Ratiometric array of conjugated polymers−fluorescent protein provides a robust mammalian cell sensor. Journal of the American Chemical Society 138, 4522-4529 (2016). *Corresponding Author

  • Rana, S.; Le, N.D.B.; Mout, R.; Saha, K.; Tonga, G.Y.; Bain, R.E.S.; Miranda, O.R.; Rotello, C.M.; Rotello, V.M. A multichannel nanosensor for instantaneous readout of cancer drug mechanisms. Nature Nanotechnology 10, 65-69 (2015).

  • Rana, S.; Le, N.D.B.; Duncan, B.; Elci, S.G.; Mout, R.; Rotello, V.M. A multichannel biosensor for rapid determination of cell surface glycomic signatures. ACS Central Science 1, 191-197 (2015).

  • Chen. K.;#  Rana, S.;# Moyano, D.F.; Xu, Y.; Guo, X.; Rotello, V.M. Differentiation of protein isoforms using gold nanoparticles through controlled ligand hydrophobicity. Nanoscale 6, 6492-6495 (2014). | #Equal contribution

  • Howes, P.D.; Rana, S.; Stevens, M.M. Plasmonic nanomaterials for biodiagnostics. Chemical Society Reviews 43, 3835-3853 (2014).

  • Rana, S.; Singla, A.K.; Bajaj, A.; Miranda, O.R.; Yan, B.; Jirik, F.R.; Rotello, V.M. Array-based sensing of metastatic cells and tissues using nanoparticle-fluorescent protein conjugates. ACS Nano 6, 8233-8240 (2012)

  • Rana, S.; Yu, X.; Patra, D.; Moyano, D.F.; Miranda, O.R.; Hussain, I.; Rotello, V.M. Control of surface tension at liquid-liquid interfaces using nanoparticles and nanoparticle-protein complexes. Langmuir 28, 2023-2027 (2012).

  • Rana, S.; Bajaj, A.; Mout, R.; Rotello, V.M. Monolayer coated gold nanoparticles for delivery applications. Advanced Drug Delivery Reviews 64, 200-216 (2012).

  • De, M.; Rana, S.; Akpinar, H.; Miranda, O.R.; Arvizo, R.R.; Bunz, U.H.F.; Rotello, V.M. Sensing of proteins in human serum using conjugates of nanoparticles and green fluorescent protein. Nature Chemistry 1, 461-465 (2009).

    For the complete list of publications, please check Google Scholar.

  • Young Investigators’ Meeting Travel Award by IndiaBioscience, 2017
  • Marie Curie International Incoming Fellowship by the European Commission, 2014
  • William E. McEwen Fellowship Award for outstanding poster presentation, University of Massachusetts Amherst, 2012
  • Graduate Student Travel Grant Award by University of Massachusetts Amherst, 2012
  • William E. McEwen Fellowship Award for outstanding poster presentation, University of Massachusetts Amherst, 2010